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. 2018 Apr 27;9(32):22802–22816. doi: 10.18632/oncotarget.24896

Figure 2. The cancer-immunity cycle in CNS malignancies.

Figure 2

T lymphocytes are shown in purple, with CAR-T modified T lymphocytes highlighted with a glow. The orange half of the circle marks out steps that can be targeted systemically, while the purple indicates steps that require intra-cranial delivery/mode of action. Abbreviations: CAR Chimeric antigen receptors; RT radiotherapy; CTLA-4 cytotoxic T-lymphocyte-associated protein 4; PD-1 Programmed cell death protein 1; PD-L1 Programmed death-ligand 1; IDO Indoleamine-pyrrole 2,3-dioxygenase; TGF-β Transforming growth factor beta.