Table 1.

ECM-associated genes and proteins reported to influence specific hallmarks of cancer^a.

	1. Self-sufficiency in growth signals	2. Insensitivity to anti-growth signals	3. Evading programmed cell death	4. Limitless replicative potential	5. Sustained angiogenesis	6. Tissue invasion and metastasis
Genes	ADAMTS1, COL/LOX, COL1, COL1A2, COL6A1, COL6A2, COL8A1, CTNNB1, ICAM1, ITGA6, ITGB1, LAMA1, LAMA2, LAMA3, LAMC2, LAMA67R, MMP10, MMP11, MMP12, MMP13, MMP14, MMP15, MMP16, MMP8, SELP, SPARC, TIMP2, TIMP3, VCAM1, VCAN	ADAMTS1, COL6A1, ICAM1, ITGB1, LAMA3, MMP10, MP11, MMP12, MP13, MMP8, SELP, TIMP2, TIMP3, VCAM1, VCAN	ADAMTS8, COL4A2, COL6A1, CTNNA1, CTNNB1, LAMA67R, LAMA1, LAMC1, MMP1, MMP10, MMP15, TIMP3, VCAM1	COL6A1	ADAMTS1, ADAMTS13, ADAMTS8, COL, COL15A1, HS, LAMB1, MMP1, PECAM1, SPARC, TIMP2, TIMP3, VCAN	ADAMTS1, ADAMTS8, ANTXR1, COL, COL1, COL12, COL12A1, COL16A1, COL1A2, COL4, COL4A2, COL4A5, COL6A1, COL6A2, COL8A1, CTHRC1, CTNNB1, ELN, FN, HAS1, HDAC, ICAM1, ITGA6, ITGB4, ITGB-α6β1, LAMA3, LAMC1, LAMC2, LAMA332, LAMA67LR, MMP1, MMP10, MMP11, MMP12, MMP13, MMP14, MMP15, MMP16, MMP2, MMP3, MMP7, MMP8, MMP9, SPARC, TIMP1, TIMP2, TIMP3, VCAM1, VCAN
Associated with Specific Cancers	BLADDER, BREAST, CERVICAL, COLON, ESOPHAGEAL, GASTRIC, GENERIC, HEAD AND NECK, LIVER, LUNG, OVARIAN, PROSTATE, UTERUS, ENDOMETRIAL	ENDOMETRIAL, BLADDER, BREAST, CERVICAL, COLON, ESOPHAGEAL, HEAD AND NECK, LIVER, LUNG, OVARIAN, UTERUS	BILE DUCT CARCINOMA, BREAST, CERVICAL, COLON, ESOPHAGEAL, LIVER, LUNG, OVARIAN, PANCREATIC, PROSTATE	PROSTATE	BRAIN, BREAST, COLON, GASTRIC, LIVER, LUNG, OVARIAN	BLADDER, BONE, BRAIN, BREAST, CERVICAL, COLON, ENDOMETRIAL, ESOPHAGEAL, GASTRIC, HEAD AND NECK, KIDNEY, LIVER, LUNG, ORAL, OVARIAN, PANCREATIC DUCTAL ADENOCARCINOMA, PROSTATE, SKIN, UTERUS
References	37	20	16	1	18	103

^aMethods for meta-review survey: The articles reported in Tables 1–4 were using Google Scholar and PubMed.; the searches were restricted to keywords within the title of the publications as well as to publications dated from 2010 to 2017. Table 4 shows the ECM-associated genes that were used as primary keywords for this table, specific cancers types (breast, liver, ovarian, and brain) were used as secondary keywords, an expansion of cancer types (prostate, head and neck, colon, oral) were used as tertiary keywords, and the generic keywords “tumor” and “cancer” were used as quaternary keywords. Search parameters began with a combination of individual primary keywords with individual secondary keywords. In the instance that combinations of individual primary and secondary keywords did not generate articles associating ECM-gene influence on the various hallmarks of cancer, the search was then expanded using individual primary and tertiary keywords. In the instance that this expansion did not assist in producing relevant articles, the search was further expanded using individual primary and quaternary keywords. On the rare occasion that no relevant articles were found using this search protocol, the restriction on publication date was removed and the search protocol was repeated. Finally, a few articles were also included in Tables 1–3 that either reported the influence of ECM-associated genes that were not listed in Table 4 or used generic descriptions of the ECM-associated genes listed in Table 4. An attempt was made to report a minimum of five articles per each individual ECM-associated gene. At the time that the search was performed, it became apparent that some ECM-associated genes from Table 4 had been investigated more thoroughly in the literature than others, which is reflected in the frequency of reported articles associated with those specific ECM-associated genes in Tables 1–3. Keywords: Primary: Specific ECM-associate genes; Secondary: breast, liver, ovarian, brain cancers; Tertiary: prostate, head and neck cancers, colon, oral cancers; Quaternary: tumor and cancer.