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The relative flexible movements of the REC lobe (gray) against the HNH (magenta) and RuvC (blue) domains are represented by the gray arrows. The binding of the sgRNA (orange) stabilizes the Cas9 molecule, whereas the binding of the target DNA (green) and Mg2+ increases the flexibility between the REC and NUC lobes. The HNH positions in the ternary complex are indicated by magenta letters.
