Table 2.
Statistically Significant Differences between Cohorts within the Large Lung Cancer Studya
glycan nodeb | CH vs C | CH vs I | CH vs II | CH vs III | CH vs IV | C vs I | C vs II | C vs III | C vs IV | I vs II | I vs III | I vs IV | II vs III | II vs IV | III vs IV |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
t-Fucose | ns | ii | ns | iiii | iiii | ii | ns | iiii | iiii | ns | ns | ns | ns | ns | ns |
t-Gal | ns | ns | ns | i | iii | ns | ns | iii | iiii | ns | ns | ns | ns | ns | ns |
2-Man | ns | ii | i | iiii | iiii | i | ns | iiii | iiii | ns | ns | ns | ns | ns | ns |
4-Glc | dddd | dd | dddd | dddd | dddd | ii | ns | i | i | ns | ns | ns | ns | ns | ns |
3-Gal | ns | ns | ns | i | i | ns | ns | i | i | ns | ns | ns | ns | ns | ns |
6-Gal | i | ns | i | iiii | iiii | ns | ns | iiii | iiii | ns | iii | iii | ii | ii | ns |
3,4-Gal | ns | ns | iiii | ns | ns | ns | iiii | i | i | iii | ns | ns | ii | ii | ns |
2,4-Man | i | i | ii | iiii | iiii | ns | ns | iiii | iiii | ns | iii | iii | i | i | ns |
2,6-Man | ii | i | iii | iiii | iiii | ns | ns | iiii | iiii | ns | iii | iii | i | i | ns |
3,6-Man | ns | ns | ns | iii | iii | ns | ns | iiii | iiii | ns | ns | ns | ns | ns | ns |
3,6-Gal | ns | ns | ns | ns | ns | ns | ns | ns | ns | ns | ns | ns | ns | ns | ns |
3,4,6-Man | i | iiii | i | ii | ii | ii | ns | ns | ns | ns | i | i | ns | ns | ns |
t-GlcNAc | ns | ns | i | iiii | iiii | ns | i | iiii | iiii | ns | ii | i | ns | ns | ns |
4-GlcNAc | i | ns | i | iiii | iiii | ns | ns | iiii | iiii | ns | ii | ii | ns | i | ns |
3-GlcNAc | ns | ns | i | iiii | iiii | ns | ns | iiii | iiii | ns | iii | iii | ns | ns | ns |
3-GalNAc | ii | ns | i | iiii | iiii | ns | ns | ii | iii | ns | ii | iii | ns | ii | ns |
3,4-GlcNAc | ns | ns | i | iiii | iiii | ns | ns | iiii | iiii | ns | iii | iii | i | ii | ns |
4,6-GlcNAc | ii | ns | ii | iiii | iiii | ns | ns | iii | iii | ns | ii | ii | ns | ns | ns |
3,6-GalNAc | iiii | iii | iii | iiii | iiii | ns | ns | ii | iii | ns | ns | ns | ns | ns | ns |
Hexose data were normalized to heavy, stable isotope labeled glucose (Glc) and HexNAc data normalized to heavy, stable isotope labeled GlcNAc.
Kruskal–Wallis test followed by Benjamini–Hochberg false discovery correction procedure where significance at the 95% confidence level is given by p < 0.05. “ns” indicates “not significant”. “i” and “d” stand for “increased” or “decreased” in the clinically more advanced cohort listed in the column header. “i” or “d” indicates p < 0.05, “ii” or “dd” indicates p < 0.01, “iii” or “ddd” indicates p < 0.001, and “iiii” and “dddd” indicates p < 0.0001. CH: certifiably healthy; C: controls; I: Stage I; II: Stage II; III: Stage III; and IV: Stage IV.