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. Author manuscript; available in PMC: 2019 Apr 15.
Published in final edited form as: J Immunol. 2018 Mar 14;200(8):2957–2964. doi: 10.4049/jimmunol.1800022

Figure 1. Pig CD74 increases cell surface expression of class II SLA proteins.

Figure 1

HEK 293T cells expressing 10 different class II SLA α and β heterodimers in the presence (black bars) or absence (red bars) of pig CD74 were tested for: (A) Binding to a monoclonal antibody, specific for class II SLA and (B) Binding of CerCLIP.1, a monoclonal antibody specific for invariant chain peptides associated with class II SLA. CD74 expression significantly increased antibody binding (p=0.002 for both assays, Wilcoxon matched-pairs sign rank test). Specific alleles making up each alpha-beta combination are indicated in table 2. DR indicates SLA-DRα/DRβ pairs, DQ represents SLA-DQα/DQβ pairs, and hybrid represent SLA-DRα/DQβ pairs.