Figure 2b:

Images in a 46-year-old postmenopausal woman with a poorly differentiated invasive ductal carcinoma with a pathologic complete response to neoadjuvant chemotherapy (NAC) who was assigned to RCB class 0 (RCB-0). Her baseline tumor had an initial maximum diameter of 2.9 cm as determined at mammography (a clinical palpation examination found the diameter to be 5.5 cm). Image a displays an axial mammogram obtained prior to chemotherapy. Images in b are sagittal diffuse optical tomography images obtained in the left and right breasts just before therapy. The images displayed refer to a time point of 15 seconds after the breath hold and show the percentage change in deoxyhemoglobin (%Δ[Hb]). Finally, image c shows time-dependent signal traces in response to a 30-second breath hold for the tumor region obtained at dynamic diffuse optical tomography just before the start of NAC (baseline) and 2 weeks after treatment initiation.