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Active efflux pumps operating in P. aeruginosa with known antibiotic substrates.
| RND system | Substrates |
|---|---|
| MexAB-OprM | β-lactams except imipenem |
| Quinolones | |
| Macrolides | |
| Tetracyclines | |
| Chloramphenicol | |
| MexCD-OprJ | Penicillin, cefepime, cefpirome, meropenem |
| Quinolones | |
| Macrolides | |
| Tetracyclines | |
| Chloramphenicol | |
| MexEF-OprN | Carbapenems |
| Quinolones | |
| MexXY-OprM | Penicillin, cefepime, cefpirome, meropenem |
| Aminoglycosides | |
| Quinolones | |
| Macrolides | |
| Tetracyclines | |
| Chloramphenicol |
