Table 3.

Activity profiling of three hit compounds, i.e. 2, 2–1 and 2–2 against a panel of HDAC isoforms.

Name	IC50 (μM)
	HDAC3	HDAC1	HDAC2	HDAC8	HDAC4	HDAC6
2	6.1	12.7	24.8	>100	>100	>100
2–1	1.3	0.957	1.78	>100	>100	>100
2–2	12.5	16.6	29.3	>100	>100	>100
Positive drug	0.043a	0.0633	0.173	4.33	1.37 b	0.0222

^aThe average from two independent tests.

^bTSA instead of SAHA was used as a positive drug for HDAC4.