Figure 5.

Inhibition of CD154-induced NF-κB activation in CD40 sensor cells by compounds 6, 14, 15, and 18 in a concentration-dependent manner. Tartrazine (TZ) and an anti-CD154 antibody (mAb; single dose, 240 nM) were included as negative and positive controls, respectively. Data are average ± SD (normalized to CD154-activated cells alone) for n = 2 independent experiments with duplicates for each condition. Smaller inset at bottom right shows the concentration response on a classic semi-log scale as used to calculate the IC₅₀ values.