Table 1.

Summary of data for compounds of the present study.

No.	Name	Formula	R1 a	R2 a	CD40 IC50 [μM]	OX40 IC50 [μM]	BAFF IC50 [μM]	TNF IC50 [μM]	NF-κB IC50 [μM]
6	DRI-C21041	C30H21N3O7S	1-SO3H	4′-NO2	0.087	317.9	0.328	>1000	19.9
7	DRI-C24041	C30H21N3O7S	4-SO3H	4′-NO2	0.299	9.34	2.007	554.6
8	DRI-21047a	C31H21F3N2O5S	1-SO3H	4′-CF3	57.85	10.07	42.18	61.07
9	DRI-C24541	C32H23N3O6	4-CO2Me	4′-NO2	55.99	>1000	685.6	795.8
10	DRI-C2105041	C30H21N3O10S2	1,5-(SO3H)2	4′-NO2	68.31	135.0	439.7	688.5
11	DRI-C2105045	C32H24N2O10S2	1,5-(SO3H)2	4′-CO2Me	60.07	120.4	540.1	456.1
12	DRI-C2104121	C30H20N4O9S	1-SO3H	2′,4′-(NO2)2	50.50	10.31	38.14	61.68
13	DRI-C2104531	C32H23N3O9S	1-SO3H	3′-NO2-4′-CO2Me	0.390	86.19	5.27	674.4
14	DRI-C21091	C36H25N3O7S	1-SO3H	4′-(4-NO2)C6H4	0.020	6.88	0.784	70.35	11.1
15	DRI-C21095	C38H28N2O7S	1-SO3H	4′-(4-CO2Me)C6H4	0.019	1.013	1.517	26.55	6.0
16	DRI-C31041	C32H25N3O7S	1-SO3H	4′-NO2	44.80	7.28	26.73	61.48
17	DRI-C41041	C28H19N3O7S	1-SO3H	4′-NO2	57.45	36.63	81.38	118.5
18	DRI-C61041	C29H20N4O7S	1-SO3H	4′-NO2	1.34	5.48	8.07	46.94	8.7
19	DRI-C61045	C31H23N3O7S	1-SO3H	4′-CO2Me	2.41	6.97	13.76	182.0

^a For numbering, see structure 6 in Scheme 1.