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Summary of documented IL-33 functions in cutaneous wound healing.
| Target cell/tissue | Stimulated activity | Reference(s) |
|---|---|---|
|
| ||
| Keratinocytes/epithelium | Scratch closure (in vitro) | 37 |
| Wound closure (in vivo) | 35–37, 40 | |
|
| ||
| Endothelial cells/vasculature | Migration (in vitro) | 34 |
| Vascular density (in vivo) | 40 | |
|
| ||
| Fibroblasts | ECM deposition (in vivo) | 35, 40 |
|
| ||
| Immune cells | Neutrophil number (in vivo) | 41 |
| M2 macrophage number (in vivo) | 35 | |
| ILC2 number (in vivo) | 36 | |
