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. Author manuscript; available in PMC: 2019 Jul 15.
Published in final edited form as: Dev Biol. 2018 Apr 22;439(2):92–101. doi: 10.1016/j.ydbio.2018.04.015

Figure 1. Loss of TFAM in the developing endoderm-derivatives is neonatal lethal with compromised lung development.

Figure 1

(A) Mice lacking TFAM in developing endoderm tissues were generated using the Shh-Cre driver. No surviving pups were observed after birth, whereas pups were present at expected Mendelian ratios one day prior to birth (Chi-squared test). (B) Whole mount images of E18.5 lungs from TFAM mutant or littermate controls (either front-lit or back-lit). Arrowheads point to transparent tips at the distal regions, which correspond to under-developed cysts upon histological examination (C). Scale bar = 50µm. Arrows point to peripheral airway differences.