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(a) S-nitrosylation directly inhibits kinase activity. SNO: S-nitrosylation; P: phosphorylation. (b) S-nitrosylation disrupts kinase-substrate interaction. (c) S-nitrosylation changes GSK3β localization and determines substrate specificity. (d) Phosphorylation and S-nitrosylation alternatively modify β-arrestin1 and β-arrestin2 to regulate GPCR internalization. (e) S-nitrosylation converts CDK5 from kinase to nitrosylase.
