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. 2018 Apr 13;472(5):749–758. doi: 10.1007/s00428-018-2354-9

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© The Author(s) 2018

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 2 — Marker expression of CIS and concomitant invasive tumor. a Cytokeratin (CK) 20 (percentage of positive cells evaluated). b GATA3 (Remmele Score). c Human epidermal growth factor receptor 2 (Her2) (DAKO Score). d Estrogen Receptor (ER) β (Remmele Score). e CK5/6 (percentage of positive cells). f CK14 (percentage of positive cells). Band indicates median, bottom, and top of box show first and third quartiles, whiskers demonstrate range of data distribution (minimum/maximum). A significant downregulation of luminal markers and an upregulation of basal markers were observed in the invasive compartment