Table 7. Unfavorable amino acid substitutions of Cap18 leading to increased hemolytic activity against horse erythrocytes.

Position	Parent Amino Acid	Hemolytic activity
		6% -10%	11%-15%	≥16%
1	G
2	L		I
3	R
4	K
5	R	W
6	L
7	R
8	K
9	F
10	R	F,L,W
11	N
12	K	W
13	I
14	K	W
15	E
16	K	A,C,F,I,L,M,V,W	S
17	L			I
18	K	A,H	Q,Y
19	K	G
20	I
21	G	F,L,Y	W
22	Q	K		S
23	K	A,I,N,V,W,Y	C,F,L,M
24	I
25	Q	C,I,L,V,W,Y		F
26	G	E,W	L,R
27	L	C,I
28	L	F,H	M
29	P	E,F,H,I,K,L,M,N,R,V,W	C	D
30	K	C,Q,W	Y
31	L
32	A	F,I	C
33	P			W
34	R	K,R
35	T	I		C
36	D	C,W,Y	F
37	Y	I,M,Q