Table 3. Structural effects of various monomeric RS1 mutations as inferred by in silico analysis.

RS1	% OF HELIX DURING MDS	% OF STRAND DURING MDS	HYDROPHILIC AREA (Å)	HYDROPHOBIC AREA (Å)	NUMBER OF DISULFIDE BONDS
WT	0.00	35.95	7163.845	707.130	2 (Cys63-Cys219, Cys 110-Cys142)
W96R	0.00	35.89	7594.86	517.153	2 (Cys63-Cys219, Cys 110-Cys142)
E72K	0.00	34.24	7599.401	479.494	2 (Cys63-Cys219, Cys 110-Cys142)
D126H	0.00	35.88	8392.535	600.462	2 (Cys63-Cys219, Cys 110-Cys142)
I196dup	0.00	36.68	7918.714	549.501	2 (Cys63-Cys220, Cys 110-Cys142)
Q129_144dup	0.00	30.61	8599.731	648.115	1 (Cys110-Cys158)
I125R	0.00	34.10	8134.669	548.585	2 (Cys63-Cys219, Cys 110-Cys142)
R197H	0.01	35.69	7640.360	471.839	2 (Cys63-Cys219, Cys 110-Cys142)

MDS, molecular dynamic simulation.