Table 6. Comparison of ERG parameters between control samples and XLRS patients showing non-secreted or secreted or protein profile.
| ERG PARAMETERS | CONTROL GROUP (N = 16 eyes) Median (IQR) | NON-SECRETED GROUP (N = 16 eyes) Median (IQR) | SECRETED GROUP (N = 12 eyes) Median (IQR) | p VALUE* |
|---|---|---|---|---|
| Amplitudes (μV) | ||||
| Dark-adapted 0.01 b-wave | 295.1 (269.5, 337.6) | 70.4 (16.9, 114.6) | 73.9 (40.1, 104.9) | <0.0001 |
| Dark-adapted 3.0 a-wave | 208.9 (165.5, 257.5) | 170.7 (76.1, 220.4) | 139.2 (95.4, 195.7) | 0.037 |
| Dark-adapted 3.0 b-wave | 483.6 (442.5, 524.7) | 168.3 (72.1, 249.4) | 170.2 (141.2, 220.7) | <0.0001 |
| Light-adapted 3.0 a-wave | 27 (25.1, 31.2) | 19.4 (12, 25.3) | 17.7 (11.6, 23.7) | 0.001 |
| Light-adapted 3.0 b-wave | 95.2 (68.4, 135.1) | 40.2 (19.8, 57.6) | 31.6 (24.2, 45.9) | <0.0001 |
| Light-adapted 30 flicker 3.0 b-wave | 60.4 (50.2, 82.0) | 25.9 (9.4, 35.0) | 18.6 (12.2, 23.5) | <0.0001 |
| Dark-adapted b/a ratio | 2.4 (2.0, 2.7) | 1.1 (0.9, 1.3) | 1.2 (1.0, 1.6) | <0.0001 |
| Light-adapted b/a ratio | 3.4 (2.4, 5.1) | 2.3 (1.5, 2.7) | 2.3 (1.5, 2.9) | 0.003 |
| Implicit times (ms) | ||||
| Dark-adapted 0.01 b-wave | 62.8 (59.6, 69.4) | 76.5 (71, 80.5) | 77.3 (74.4, 82.8) | <0.0001 |
| Dark-adapted 3.0 a-wave | 17.5 (16.5, 17.9) | 18.5 (17, 20.9) | 20.3 (19.5, 21.8) | <0.0001 |
| Dark-adapted 3.0 b-wave | 43.3 (42.1, 44.9) | 39.3 (35.6, 41.9) | 50.3 (46.6, 54) | <0.0001 |
| Light-adapted 3.0 a-wave | 16.8 (16.5, 17.5) | 18.5 (17.5, 20.0) | 19.3 (17, 20) | 0.003 |
| Light-adapted 3.0 b-wave | 27.5 (27, 28.4) | 30 (28.5, 33.9) | 31.3 (29.5, 33.5) | <0.0001 |
| Light-adapted 30 flicker 3.0 b-wave | 25 (24.5, 25.5) | 29.5 (28, 31.9) | 29.5 (28.1, 31.6) | <0.0001 |
μv, microvolts; ms, milliseconds; IQR, inter quartile range (25th percentile, 75th percentile).
*p value = 0.02 (bonferroni correction)