Table 6.

Comparison of the P. aeruginosa status according to the Leeds criteria vs. clinicians’ decision, stratified according to different subgroups

	Sheffield dataset (n = 185)			ACtiF pilot dataset (n = 62)
	Number of adults in each subgroup (%)	Agreement between the Leeds criteria and clinicians’ decision, Cohen’s kappa coefficient (95% CI)	‘Sensitivity’ of the Leeds criteria in diagnosing chronic P. aeruginosa compared to clinicians’ decision (95% CI)	Number of adults in each subgroup (%)	Agreement between the Leeds criteria and clinicians’ decision, Cohen’s kappa coefficient (95% CI)	‘Sensitivity’ of the Leeds criteria in diagnosing chronic P. aeruginosa compared to clinicians’ decision (95% CI)
Overall	185	0.72 (0.64–0.80)	0.75 (0.66–0.83)	62	0.82 (0.74–0.89)	0.85 (0.69–0.95)
Subgroups based on microbiology samples
Cough swabs > sputum samples (the ‘more difficult to agree’ subgroup)	77 (41.6)	0.54 (0.40–0.69)	0.38 (0.20–0.59)	5 (8.1)	N/A (all 5 adults were ‘no P. aeruginosa’ according to the Leeds criteria)	N/A (all 5 adults were non-chronic P. aeruginosa)
Sputum samples ≥ cough swabs (the ‘easier to agree’ subgroup)	108 (58.4)	0.78 (0.67–0.90)	0.88 (0.78–0.94)	57 (91.9)	0.78 (0.64–0.93)	0.85 (0.69–0.95)
Subgroups based on age
Age ≤ 25 years (the ‘more difficult to agree’ subgroup)	85 (45.9)	0.60 (0.47–0.72)	0.53 (0.34–0.69)	24 (38.7)	0.72 (0.48–0.95)	0.75 (0.43–0.95)
Age > 25 years (the ‘easier to agree’ subgroup)	100 (54.1)	0.82 (0.72–0.93)	0.88 (0.78–0.95)	38 (61.3)	0.82 (0.65–0.98)	0.91 (0.71–0.99)