Table 3.

Comparison of MRI parameters between responders and non-responders (n = 35)

FMI parameters	Responders (%)	Non-responders (%)	p value	ROC (AUC)
Primary (27 ROIs)
ADC (×10−3 mm2/s)
Baseline	1.02 ± 0.19	1.22 ± 0.14	0.009*	0.829
Δ post-wk 1	18.9 ± 25.5	5.1 ± 33.7	0.274	–
Δ post-wk 2	33.7 ± 15.1	11.0 ± 9.0	0.000*	0.937
R2*(s−1)
Baseline	34.3 ± 10.5	31.4 ± 10.0	0.685	–
Δ post-wk 1	0.7 ± 23.6	−5.3 ± 25.6	0.555	–
Δ post-wk 2	−5.3 ± 25.6	4.0 ± 25.4	0.791	–
Ktrans (min−1)
Baseline	0.202 ± 0.040	0.194 ± 0.049	0.735	–
Δ post-wk 1	47.3 ± 41.6	28.2 ± 27.3	0.331	–
Δ post-wk 2	115.4 ± 117.2	13.9 ± 51.2	0.012*	0.813
Ve
Baseline	0.256 ± 0.055	0.318 ± 0.055	0.003*	0.864
Δ post-wk 1	6.9 ± 5.9	8.1 ± 22.9	0.836	–
Δ post-wk 2	12.9 ± 9.8	0.1 ± 16.6	0.047*	0.774
Vp (×10−3)
Baseline	8.5 ± 7.4	2.7 ± 5.6	0.072	–
Δ post-wk 1	−0.52 ± 0.73	−0.03 ± 0.86	0.219	–
Δ post-wk 2	−0.53 ± 0.75	−0.16 ± 2.06	0.288	–
Lymph nodes (36 ROIs)
ADC (×10−3 mm2/s)
Baseline	1.059 ± 0.211	1.086 ± 0.091	0.456	–
Δ post-wk 1	13.6 ± 12.2	18.0 ± 7.4	0.239	–
Δ post-wk 2	33.4 ± 19.0	30.1 ± 4.4	0.900	–
R2*(s−1)
Baseline	20.7 ± 4.7	21.1 ± 2.3	0.611	–
Δ post-wk 1	3.8 ± 18.4	4.5 ± 10.8	0.677	–
Δ post-wk 2	4.4 ± 23.0	7.4 ± 8.3	0.445	–
Ktrans (min−1)
Baseline	0.167 ± 0.044	0.204 ± 0.81	0.184	–
Δ post-wk 1	45.5 ± 42.5	64.6 ± 96.4	1.000	–
Δ post-wk 2	34.5 ± 59.7	−5.0 ± 31.3	0.102	–
Ve
Baseline	0.241 ± 0.079	0.339 ± 0.120	0.020*	0.783
Δ post-wk 1	6.8 ± 7.1	13.8 ± 14.7	0.244	–
Δ post-wk 2	11.9 ± 10.3	8.5 ± 4.3	0.694	–
Vp (×10−3)
Baseline	4.5 ± 5.2	1.1 ± 2.6	0.229	–
Δ post-wk 1	−0.18 ± 0.50	−0.13 ± 0.28	0.944	–
Δ post-wk 2	−0.12 ± 0.67	−0.10 ± 0.30	0.813	–

*statistically significant difference