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. 2018 Apr;93(4):1000–1007. doi: 10.1016/j.kint.2017.09.011

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© 2017 International Society of Nephrology.

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Association between usual C-reactive protein (CRP) and the risk of (a) major vascular events and (b) nonvascular events, and the association between usual low-density lipoprotein cholesterol (LDL-C) and the risk of (c) major vascular events and (d) nonvascular events. Hazard ratios (HRs) adjusted for age, sex, ethnicity, treatment allocation, prior diabetes, prior vascular disease, smoking, body mass index, high-density lipoprotein cholesterol, and renal status are noted (above squares), along with numbers of events (below squares). Average HR (95% confidence interval [CI]) throughout the range of values studied (i.e., assuming a log-linear relationship for LDL−C and a log-log-linear relationship for CRP), corresponding to about 1 SD difference in the usual LDL−C/log CRP.