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. 2018 Jan 24;135(4):601–615. doi: 10.1007/s00401-018-1810-6

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 5 — MGMT score in function of the molecular subtype in LGG. The MGMT methylation scores for the three distinct molecular subtypes (wt, CIMP-/IDHwt; IDHmt, CIMP+ non-codel; IDHmt codel, CIMP+ codel) separated by WHO tumor grade, are shown for the four datasets (EORTC 22033, TCGA1 & 2, AGlioma). The p values of the comparison between codeleted and non-codeleted samples are based on the Welch’s t test for each dataset. The dashed line indicates the MGMT-STP27 cut-off [logit(0.358)]