Table 1.
Baseline characteristics stratified by derivation and validation cohort
| All patients n = 513 |
Derivation cohort n = 200 (39.0%) |
Validation cohort n = 313 (61.0%) |
p-value | |
|---|---|---|---|---|
| Clinical parameters | ||||
| Age (years) | 57.4 ± 17.5 | 57.7 ± 17.3 | 57.3 ± 17.7 | 0.986 |
| Female (%) | 49.1 | 50.0 | 48.6 | 0.751 |
| BMI (kg/m2) | 27.3 ± 5.6 | 27.4 ± 5.8 | 27.2 ± 5.4 | 0.845 |
| Hypertension (%) | 68.9 | 68.3 | 69.3 | 0.821 |
| Atrial fibrillation (%) | 28.2 | 24.1 | 31.0 | 0.120 |
| Diabetes (%) | 16.4 | 16.3 | 16.5 | 0.959 |
| CAD (%) | 25.8 | 32.6 | 21.0 | 0.007 |
| Previous PCI (%) | 10.6 | 12.1 | 9.5 | 0.401 |
| Previous CABG (%) | 4.0 | 5.1 | 3.2 | 0.318 |
| Previous MI (%) | 9.6 | 13.6 | 6.7 | 0.017 |
| Previous stroke (%) | 3.7 | 4.0 | 3.6 | 0.819 |
| Conventional hematocrit (%) | 39.9 ± 4.7 | 40.2 ± 4.4 | 39.9 ± 4.8 | 0.490 |
| eGFR (ml/min/1.73 m2) | 78.0 ± 25.9 | 80.1 ± 27.8 | 76.5 ± 24.5 | 0.187 |
| Serum NT-proBNP (pg/ml) | 1493.9 ± 3884.2 | 1319.4 ± 3583.5 | 1611.3 ± 4076.8 | 0.126 |
| Referral diagnosis | 0.076 | |||
| Heart failure (%) | 48.0 | 48.5 | 47.6 | – |
| VHD (%) | 18.3 | 14.5 | 20.8 | – |
| CAD (%) | 10.7 | 14.5 | 8.3 | – |
| Others (%) | 23.0 | 22.5 | 23.3 | – |
| Cardiac magnetic resonance imaging parameters | ||||
| LA diameter | 59.3 ± 10.1 | 58.5 ± 9.8 | 59.9 ± 10.3 | 0.099 |
| RA diameter | 59.4 ± 9.6 | 58.4 ± 8.6 | 60.0 ± 10.2 | 0.082 |
| IVS (mm) | 11.7 ± 3.3 | 11.8 ± 2.9 | 11.7 ± 3.5 | 0.426 |
| LV mass (g) | 119.8 ± 46.7 | 118.2 ± 38.4 | 121.1 ± 52.2 | 0.619 |
| LVEF (%) | 61.7 ± 11.8 | 62.2 ± 10.5 | 61.4 ± 12.5 | 0.730 |
| LVEDVi (ml) | 76.9 ± 24.6 | 74.5 ± 23.6 | 78.4 ± 25.2 | 0.066 |
| Cardiac index (l/min) | 3.1 ± 0.9 | 3.1 ± 0.9 | 3.1 ± 0.9 | 0.438 |
| RVEF (%) | 55.9 ± 10.1 | 56.4 ± 9.2 | 55.7 ± 10.7 | 0.499 |
| RVEDVi (ml) | 76.9 ± 20.7 | 76.6 ± 20.4 | 77.1 ± 21.0 | 0.834 |
| LGE (% of LV mass)a | 4.0 ± 7.3 | 4.3 ± 7.4 | 3.8 ± 7.2 | 0.729 |
| Native myocardial T1-time (ms) | 990.8 ± 55.3 | 991.4 ± 54.5 | 990.4 ± 56.0 | 0.151 |
| Native blood T1-time (ms) | 1570.6 ± 117.8 | 1561.4 ± 101.8 | 1576.5 ± 126.7 | 0.133 |
| Conventional ECV (%) | 28.4 ± 6.8 | 28.8 ± 7.8 | 28.2 ± 6.1 | 0.227 |
Values are mean ± SD or %
BMI indicates body mass index, CAD coronary artery disease, PCI percutaneous coronary intervention, CABG coronary artery bypass graft surgery, MI myocardial infarction, eGFR estimated glomerular filtration rate, VHD valvular heart disease, LA left atrium, RA right atrium, IVS interventricular septal thickness, LV left ventricle, LVEF and RVEF left and right ventricular ejection fraction, LVEDVi and RVEDVi left and right ventricular end-diastolic volume indexed to body surface area (BSA), LGE late gadolinium enhancement, ECV extracellular volume, NT-proBNP N‑terminal pro brain-type natriuretic peptide
aamong patients with myocardial infarction