Fig 6. Cry5B and pyrantel in combination are synergistic in vivo against hookworm infections in hamsters.

Effects of individual treatment of Cry5B alone or pyrantel alone and combination treatment of Cry5B plus pyrantel at indicated doses on (A) intestinal hookworm burdens and (B) fecal egg counts in hookworm-infected hamsters. Black arrow indicates the effect of the combination of Cry5B and pyrantel at ratio of 3:1 (1 mg/kg Cry5B + 0.33 mg/kg pyrantel), showing greater than expected impact based on individual doses or next highest combination dose. PYR = pyrantel.