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. 2018 Mar 21;19(4):925. doi: 10.3390/ijms19040925

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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In vivo tumor growth curves showing the effects of ²¹²Pb-225.28 or ²¹²Pb-F3-C25 on human TNBC xenograft growth inhibition. Groups of mice (n = 10/group) bearing small SUM159 tumors either were left untreated (filled circles) or injected i.v. with 0.33 MBq ²¹²Pb-F3-C25 (open circles) or with 0.14 MBq (filled squares), 0.30 MBq (upward triangles), or 0.48 MBq (downward triangles) ²¹²Pb-225.28. Data were plotted as mean percent change (±standard error of the mean) in normalized tumor volume over time relative to the initial volume at the time of injection with the RIC, and analyzed by one-way ANOVA with Bonferroni’s comparison. ** p < 0.01 or *** p < 0.001 vs. ²¹²Pb-F3-C25 at day 29 after dosing.