Table 1.
In vitro binding analysis of 212Pb-225.28 to human triple-negative breast cancer (TNBC) cells and cancer-initiating cells (CICs).
aKd ± S.E.M. (nmol/L) | a Binding Sites/Cell ± SEM (×103) | Internalization (%) | |
---|---|---|---|
Adherent SUM159 | 0.6 ± 0.1 | 29 ± 4.2 | 56 |
CIC SUM159 | 0.3 ± 0.1 | 49 ± 12 | 57 |
Adherent 2LMP | 0.5 ± 0.1 | b 3.4 | 49 |
CIC 2LMP | 0.5 ± 0.2 | b 7.7 | 47 |
a Data are presented as the mean ± SEM of 1–3 individual experiments, with each experiment performed with duplicate wells. b Mean of a single experiment performed with duplicate wells.