Table A1.
Significantly changed genes enriched in different Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways (represented by p-values) in progenitor-like cells cultured in vitro compared to pancreatic single cells.
| Pathway Name | Significantly Enriched Genes | All Genes of Pathway | p-Value |
|---|---|---|---|
| Metabolic pathways | 543 | 1187 | 3.46 × 10−32 |
| Oxidative phosphorylation | 84 | 135 | 5.07 × 10−12 |
| Protein processing in endoplasmic reticulum | 92 | 162 | 5.33 × 10−10 |
| PI3K-Akt signaling pathway | 152 | 334 | 0.000000555 |
| Aminoacyl-tRNA biosynthesis | 28 | 41 | 0.00000586 |
| HIF-1 signaling pathway | 59 | 113 | 0.0000266 |
| Pyruvate metabolism | 25 | 41 | 0.000297 |
| MAPK signaling pathway | 109 | 252 | 0.000361 |
| Glycine, serine and threonine metabolism | 23 | 39 | 0.001 |
| Fatty acid metabolism | 26 | 46 | 0.00115 |
| Citrate cycle (TCA cycle) | 19 | 31 | 0.00146 |
| N-Glycan biosynthesis | 27 | 49 | 0.00155 |
| Notch signaling pathway | 26 | 49 | 0.00379 |
| Cysteine and methionine metabolism | 20 | 36 | 0.0055 |
| Amino sugar and nucleotide sugar metabolism | 25 | 48 | 0.00616 |
| Maturity onset diabetes of the young | 15 | 26 | 0.01 |
| Glutathione metabolism | 25 | 50 | 0.0118 |
| Fructose and mannose metabolism | 20 | 38 | 0.0119 |
| Pentose phosphate pathway | 16 | 29 | 0.0138 |
| Beta alanine metabolism | 16 | 29 | 0.0138 |
| Insulin signaling pathway | 58 | 137 | 0.0164 |
| Glyoxylate and dicarboxylate metabolism | 14 | 25 | 0.0178 |
| Alanine, aspartate and glutamate metabolism | 17 | 32 | 0.0178 |
| Purine metabolism | 67 | 165 | 0.0271 |
| Porphyrin and chlorophyll metabolism | 21 | 43 | 0.0273 |
| Sphingolipid metabolism | 20 | 41 | 0.0313 |
| Pyrimidine metabolism | 41 | 96 | 0.0356 |
| D-Glutamine and D-glutamate metabolism | 3 | 3 | 0.0383 |
| TGF-beta signaling pathway | 36 | 84 | 0.0451 |