Table 1.
List of the differentially expressed probe sets after treatment with 100 nM EVE.
| Probe ID | Fold Change | Regulation | Symbol | Entrez Gene ID | Definition |
|---|---|---|---|---|---|
| 4760626 | 2.275 | Up | MMP12 | 4321 | matrix metallopeptidase 12 (macrophage elastase), mRNA. |
| 4780209 | 2.218 | Up | MMP12 | 4321 | matrix metallopeptidase 12 (macrophage elastase) mRNA. |
| 670041 | 1.925 | Up | AKAP12 | 9590 | A kinase (PRKA) anchor protein (gravin) 12, transcript variant 2, mRNA. |
| 6770746 | 1.903 | Up | LOC728715 | 728715 | similar to hCG38149 (LOC728715), mRNA. |
| 4640086 | 1.814 | Up | FOXQ1 | 94234 | forkhead box Q1, mRNA. |
| 2810246 | 1.808 | Up | LBH | 81606 | limb bud and heart development homolog (mouse) (LBH), mRNA. |
| 6330270 | 1.804 | Up | GPC4 | 2239 | glypican 4, mRNA. |
| 6620201 | 1.789 | Up | KLHL24 | 54800 | kelch-like 24 (Drosophila), mRNA. |
| 5690687 | 1.783 | Up | CTGF | 1490 | connective tissue growth factor, mRNA. |
| 5420577 | 1.775 | Up | CLCA4 | 22802 | chloride channel, calcium activated, family member 4, mRNA. |
| 2640292 | 1.769 | Up | CTGF | 1490 | connective tissue growth factor, mRNA. |
| 1070477 | 1.753 | Up | ALDH1A1 | 216 | aldehyde dehydrogenase 1 family, member A1, mRNA. |
| 3130301 | 1.729 | Up | PIM1 | 5292 | pim-1 oncogene, mRNA. |
| 6620008 | 1.705 | up | KAL1 | 3730 | Kallmann syndrome 1 sequence, mRNA. |
| 4040576 | 1.704 | up | IL6 | 3569 | interleukin 6 (interferon, beta 2), mRNA. |
| 1820315 | 1.677 | up | C4orf26 | 152816 | chromosome 4 open reading frame 26 (C4orf26), mRNA. |
| 1990142 | 1.671 | up | C20orf114 | 92747 | chromosome 20 open reading frame 114 (C20orf114), mRNA. |
| 1940647 | 1.668 | up | HBP1 | 26959 | HMG-box transcription factor 1, mRNA. |
| 2640324 | 1.665 | up | SLC46A3 | 283537 | solute carrier family 46, member 3, mRNA. |
| 3800241 | 1.651 | up | CDH6 | 1004 | cadherin 6, type 2, K-cadherin (fetal kidney), mRNA. |
| 6110736 | 1.646 | up | IRS2 | 8660 | insulin receptor substrate 2, mRNA. |
| 4610056 | 1.641 | up | FLRT2 | 23768 | fibronectin leucine rich transmembrane protein 2, mRNA. |
| 6420687 | 1.638 | up | PLUNC | 51297 | palate, lung and nasal epithelium carcinoma associated, transcript variant 2, mRNA. |
| 6420465 | 1.625 | up | GABARAPL1 | 23710 | GABA(A) receptor-associated protein like 1, mRNA. |
| 4780128 | 1.625 | up | ATF3 | 467 | activating transcription factor 3, transcript variant 4, mRNA. |
| 160242 | 1.622 | up | C13orf15 | 28984 | chromosome 13 open reading frame 15 (C13orf15), mRNA. |
| 2650709 | 1.620 | up | CDH11 | 1009 | cadherin 11, type 2, OB-cadherin (osteoblast), mRNA. |
| 2230767 | 1.615 | up | LOC387825 | 387825 | misc_RNA (LOC387825), miscRNA. |
| 6860228 | 1.610 | up | C5orf41 | 153222 | chromosome 5 open reading frame 41 (C5orf41), mRNA. |
| 6510754 | 1.609 | up | ALDH1A1 | 216 | aldehyde dehydrogenase 1 family, member A1, mRNA. |
| 1980255 | 1.605 | up | RNF39 | 80352 | ring finger protein 39, transcript variant 2, mRNA. |
| 6840491 | 1.604 | up | C5orf41 | 153222 | chromosome 5 open reading frame 41 (C5orf41), mRNA. |
| 4280228 | 1.595 | up | IVNS1ABP | 10625 | influenza virus NS1A binding protein, mRNA. |
| 5080021 | 1.593 | up | BIRC3 | 330 | baculoviral IAP repeat-containing 3, transcript variant 1, mRNA. |
| 6400131 | 1.589 | up | CYP24A1 | 1591 | cytochrome P450, family 24, subfamily A, polypeptide 1, nuclear gene encoding mitochondrial protein, mRNA. |
| 7160239 | 1.580 | up | FOSB | 2354 | FBJ murine osteosarcoma viral oncogene homolog B, mRNA. |
| 380689 | 1.578 | up | TSC22D1 | 8848 | TSC22 domain family, member 1, transcript variant 1, mRNA. |
| 3060095 | 1.574 | up | COL12A1 | 1303 | collagen, type XII, alpha 1, transcript variant short, mRNA. |
| 1410209 | 1.571 | up | SGK1 | 6446 | serum/glucocorticoid regulated kinase 1, transcript variant 1, mRNA. |
| 2190553 | 1.556 | up | FZD6 | 8323 | frizzled homolog 6 (Drosophila), mRNA. |
| 4570075 | 1.544 | up | KIAA1641 | 57730 | KIAA1641, transcript variant 7, mRNA. |
| 5090626 | 1.540 | up | FAP | 2191 | fibroblast activation protein, alpha, mRNA. |
| 6620538 | 1.540 | up | UBL3 | 5412 | ubiquitin-like 3, mRNA. |
| 5960398 | 1.537 | up | NT5E | 4907 | 5′-nucleotidase, ecto (CD73), mRNA. |
| 5570731 | 1.533 | up | C8orf4 | 56892 | chromosome 8 open reading frame 4 (C8orf4), mRNA. |
| 830639 | 1.531 | up | LOC653778 | 653778 | similar to solute carrier family 25, member 37 (LOC653778), mRNA. |
| 3290187 | 1.529 | up | PCMTD1 | 115294 | protein-l-isoaspartate (d-aspartate) O-methyltransferase domain containing 1 (PCMTD1), mRNA. |
| 3440670 | 1.517 | up | LOC402251 | 402251 | similar to eukaryotic translation elongation factor 1 alpha 2 (LOC402251), mRNA. |
| 630315 | 1.514 | up | DHRS9 | 10170 | dehydrogenase/reductase (SDR family) member 9, transcript variant 1, mRNA. |
| 1410161 | 1.513 | up | KLHL5 | 51088 | kelch-like 5 (Drosophila), transcript variant 3, mRNA. |
| 4150575 | 1.513 | up | LETMD1 | 25875 | LETM1 domain containing 1, transcript variant 2, mRNA. |
| 7210497 | 1.513 | up | NUAK1 | 9891 | NUAK family, SNF1-like kinase, 1, mRNA. |
| 1240440 | 1.511 | up | TXNIP | 10628 | thioredoxin interacting protein, mRNA. |
| 4760747 | 1.509 | up | TPST1 | 8460 | tyrosylprotein sulfotransferase 1, mRNA. |
| 2360220 | 1.508 | up | MATR3 | 9782 | matrin 3, transcript variant 1, mRNA. |
| 3800431 | 1.508 | up | RCOR3 | 55758 | REST corepressor 3, mRNA. |
| 4390450 | 1.504 | up | SGK | 6446 | serum/glucocorticoid regulated kinase, mRNA. |
| 2450465 | 1.503 | up | CYBRD1 | 79901 | cytochrome b reductase 1, mRNA. |
| 6110053 | 1.501 | up | ZNF32 | 7580 | zinc finger protein 32, transcript variant 2, mRNA. |
| 4570398 | 1.501 | up | F2R | 2149 | coagulation factor II (thrombin) receptor, mRNA. |
| 3800050 | −1.503 | down | ADCY3 | 109 | adenylate cyclase 3, mRNA. |
| 5900008 | −1.504 | down | KLK11 | 11012 | kallikrein-related peptidase 11, transcript variant 2, mRNA. |
| 5080605 | −1.504 | down | SNRPA1 | 6627 | small nuclear ribonucleoprotein polypeptide A′, mRNA. |
| 4560541 | −1.521 | down | MLKL | 197259 | mixed lineage kinase domain-like, mRNA. |
| 520682 | −1.523 | down | CPA4 | 51200 | carboxypeptidase A4, mRNA. |
| 4010296 | −1.527 | down | RNASE1 | 6035 | ribonuclease, RNase A family, 1 (pancreatic), transcript variant 1, mRNA. |
| 6350161 | −1.530 | down | LCP1 | 3936 | lymphocyte cytosolic protein 1 (l-plastin), mRNA. |
| 4730605 | −1.532 | down | AURKA | 6790 | aurora kinase A, transcript variant 5, mRNA. |
| 6840075 | −1.532 | down | NP | 4860 | nucleoside phosphorylase, mRNA. |
| 6770187 | −1.533 | down | SPRR2A | 6700 | small proline-rich protein 2A, mRNA. |
| 870131 | −1.533 | down | HSPA5 | 3309 | heat shock 70 kDa protein 5 (glucose-regulated protein, 78 kDa), mRNA. |
| 1570193 | −1.535 | down | ARHGDIB | 397 | Rho GDP dissociation inhibitor (GDI) beta, mRNA. |
| 2450167 | −1.537 | down | RPL29 | 6159 | ribosomal protein L29, mRNA. |
| 7510709 | −1.540 | down | CEP55 | 55165 | centrosomal protein 55 kDa, mRNA. |
| 2350465 | −1.544 | down | RPL29 | 6159 | ribosomal protein L29, mRNA. |
| 160097 | −1.546 | down | MELK | 9833 | maternal embryonic leucine zipper kinase, mRNA. |
| 3930703 | −1.547 | down | WDR4 | 10785 | WD repeat domain 4, transcript variant 2, mRNA. |
| 1170066 | −1.554 | down | SULT2B1 | 6820 | sulfotransferase family, cytosolic, 2B, member 1, transcript variant 1, mRNA. |
| 2070520 | −1.556 | down | CDCA7 | 83879 | cell division cycle associated 7, transcript variant 1, mRNA. |
| 6550048 | −1.559 | down | DHCR7 | 1717 | 7-dehydrocholesterol reductase, mRNA. |
| 5310634 | −1.566 | down | FASN | 2194 | fatty acid synthase, mRNA. |
| 6560494 | −1.566 | down | ARTN | 9048 | artemin, transcript variant 2, mRNA. |
| 5860348 | −1.568 | down | SC4MOL | 6307 | sterol-C4-methyl oxidase-like, transcript variant 2, mRNA. |
| 5270112 | −1.570 | down | HMGCS1 | 3157 | 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble), transcript variant 2, mRNA. |
| 5690274 | −1.571 | down | MCM6 | 4175 | minichromosome maintenance complex component 6, mRNA. |
| 940487 | −1.573 | down | FUT3 | 2525 | fucosyltransferase 3 (galactoside 3(4)-l-fucosyltransferase, Lewis blood group), transcript variant 4, mRNA. |
| 5810154 | −1.580 | down | ALOX15B | 247 | arachidonate 15-lipoxygenase, type B, transcript variant b, mRNA. |
| 870546 | −1.581 | down | MAD2L1 | 4085 | MAD2 mitotic arrest deficient-like 1 (yeast), mRNA. |
| 6020139 | −1.588 | down | KLK7 | 5650 | kallikrein-related peptidase 7, transcript variant 1, mRNA. |
| 4250156 | −1.589 | down | EBP | 10682 | emopamil binding protein (sterol isomerase), mRNA. |
| 10341 | −1.599 | down | SHMT2 | 6472 | serine hydroxymethyltransferase 2 (mitochondrial), nuclear gene encoding mitochondrial protein, mRNA. |
| 5360678 | −1.602 | down | DHCR7 | 1717 | 7-dehydrocholesterol reductase, transcript variant 1, mRNA. |
| 6580059 | −1.610 | down | UCP2 | 7351 | uncoupling protein 2 (mitochondrial, proton carrier), nuclear gene encoding mitochondrial protein, mRNA. |
| 5090278 | −1.610 | down | GPX2 | 2877 | glutathione peroxidase 2 (gastrointestinal), mRNA. |
| 3940673 | −1.617 | down | LOC728285 | 728285 | similar to keratin associated protein 2-4 (LOC728285), mRNA. |
| 2650564 | −1.623 | down | RARRES3 | 5920 | retinoic acid receptor responder (tazarotene induced) 3, mRNA. |
| 360367 | −1.625 | down | PCDH7 | 5099 | protocadherin 7, transcript variant a, mRNA. |
| 7560364 | −1.635 | down | LOC729779 | 729779 | misc_RNA (LOC729779), miscRNA. |
| 780528 | −1.635 | down | CKS2 | 1164 | CDC28 protein kinase regulatory subunit 2, mRNA. |
| 5960224 | −1.636 | down | PTTG3P | 26255 | pituitary tumor-transforming 3 (pseudogene), non-coding RNA. |
| 4730196 | −1.653 | down | TK1 | 7083 | thymidine kinase 1, soluble, mRNA. |
| 1510296 | −1.656 | down | ASNS | 440 | asparagine synthetase, transcript variant 1, mRNA. |
| 1190142 | −1.657 | down | EMILIN2 | 84034 | elastin microfibril interfacer 2, mRNA. |
| 1170170 | −1.662 | down | STC2 | 8614 | stanniocalcin 2, mRNA. |
| 2140128 | −1.670 | down | SCD | 6319 | stearoyl-CoA desaturase (delta-9-desaturase), mRNA. |
| 5360070 | −1.674 | down | CCNB2 | 9133 | cyclin B2, mRNA. |
| 3990619 | −1.675 | down | TOP2A | 7153 | topoisomerase (DNA) II alpha 170 kDa, mRNA. |
| 3780047 | −1.679 | down | GBP6 | 163351 | guanylate binding protein family, member 6, mRNA. |
| 2000148 | −1.683 | down | IFIT1 | 3434 | interferon-induced protein with tetratricopeptide repeats 1, transcript variant 2, mRNA. |
| 2070494 | −1.700 | down | PRC1 | 9055 | protein regulator of cytokinesis 1, transcript variant 2, mRNA. |
| 10414 | −1.704 | down | PTTG1 | 9232 | pituitary tumor-transforming 1, mRNA. |
| 2940110 | −1.720 | down | UHRF1 | 29128 | ubiquitin-like with PHD and ring finger domains 1, transcript variant 1, mRNA. |
| 1510291 | −1.733 | down | PTTG1 | 9232 | pituitary tumor-transforming 1, mRNA. |
| 1780446 | −1.739 | down | PCK2 | 5106 | phosphoenolpyruvate carboxykinase 2 (mitochondrial), nuclear gene encoding mitochondrial protein, transcript variant 1, mRNA. |
| 1660521 | −1.745 | down | SPRR2D | 6703 | small proline-rich protein 2D, mRNA. |
| 730689 | −1.763 | down | LOC652595 | 652595 | similar to U2 small nuclear ribonucleoprotein A (U2 snRNP-A) (LOC652595), mRNA. |
| 5090754 | −1.766 | down | KIAA0101 | 9768 | KIAA0101, transcript variant 1, mRNA. |
| 5080139 | −1.789 | down | PRSS3 | 5646 | protease, serine, 3 (mesotrypsin), mRNA. |
| 3800452 | −1.805 | down | EMP3 | 2014 | epithelial membrane protein 3, mRNA. |
| 1230047 | −1.810 | down | CBS | 875 | cystathionine-beta-synthase, mRNA. |
| 6370615 | −1.858 | down | TGM1 | 7051 | transglutaminase 1 (K polypeptide epidermal type I, protein-glutamine-gamma-glutamyltransferase), mRNA. |
| 5310471 | −1.894 | down | UBE2C | 11065 | ubiquitin-conjugating enzyme E2C, transcript variant 6, mRNA. |
| 7380719 | −1.897 | down | IGFBP6 | 3489 | insulin-like growth factor binding protein 6, mRNA. |
| 940327 | −1.907 | down | KLK13 | 26085 | kallikrein-related peptidase 13, mRNA. |
| 520195 | −1.914 | down | TMEM79 | 84283 | transmembrane protein 79, mRNA. |
| 4040398 | −1.954 | down | MAL | 4118 | mal, T-cell differentiation protein, transcript variant d, mRNA. |
| 1990630 | −1.979 | down | TRIB3 | 57761 | tribbles homolog 3 (Drosophila), mRNA. |
| 430446 | −1.996 | down | KRT81 | 3887 | keratin 81, mRNA. |
| 4260368 | −2.022 | down | UBE2C | 11065 | ubiquitin-conjugating enzyme E2C, transcript variant 3, mRNA. |
| 290767 | −2.038 | down | KRTDAP | 388533 | keratinocyte differentiation-associated protein, mRNA. |
| 6520139 | −2.046 | down | FGFR3 | 2261 | fibroblast growth factor receptor 3 (achondroplasia, thanatophoric dwarfism), transcript variant 2, mRNA. |
| 620102 | −2.046 | down | MALL | 7851 | mal, T-cell differentiation protein-like, mRNA. |
| 5870653 | −2.050 | down | LOC651397 | 651397 | misc_RNA (LOC651397), miscRNA. |
| 4050398 | −2.071 | down | KLK12 | 43849 | kallikrein-related peptidase 12, transcript variant 1, mRNA. |
| 7330753 | −2.102 | down | ACAT2 | 39 | acetyl-Coenzyme A acetyltransferase 2, mRNA. |
| 4900458 | −2.147 | down | KRT14 | 3861 | keratin 14 (epidermolysis bullosa simplex, Dowling-Meara, Koebner), mRNA. |
| 540546 | −2.283 | down | KRT4 | 3851 | keratin 4, mRNA. |
| 1500010 | −2.322 | down | CDC20 | 991 | cell division cycle 20 homolog (S. cerevisiae), mRNA. |
| 6550356 | −2.430 | down | SPRR2C | 6702 | small proline-rich protein 2C (pseudogene), non-coding RNA. |
| 4850674 | −2.452 | down | PSAT1 | 29968 | phosphoserine aminotransferase 1, transcript variant 2, mRNA. |
| 5890400 | −2.577 | down | SPRR2E | 6704 | small proline-rich protein 2E, mRNA. |
| 240086 | −2.608 | down | PHGDH | 26227 | phosphoglycerate dehydrogenase, mRNA. |
| 7650441 | −2.696 | down | FGFBP1 | 9982 | fibroblast growth factor binding protein 1, mRNA. |
| 5810546 | −2.894 | down | SPRR2E | 6704 | small proline-rich protein 2E, mRNA. |
| 7330184 | −2.933 | down | SPRR1A | 6698 | small proline-rich protein 1A, mRNA. |
| 2230035 | −2.936 | down | KRT13 | 3860 | keratin 13, transcript variant 2, mRNA. |
| 4610131 | −3.284 | down | SPRR3 | 6707 | small proline-rich protein 3, transcript variant 1, mRNA. |
In red up-regulated and in green down-regulated genes in BE63/3 cells treated with 100 nM EVE compared to CTR.