Table 2.
List of pathways differentially regulated after 100 nM EVE.
| Pathways | Adj. p Value | Associated Genes |
|---|---|---|
| Epidermis development | 1.24 × 10−6 | ALOX15B, CTGF, FOXQ1, FZD6, KLK7, KRT14, RNASE1, SPRR1A, SPRR2A, SPRR2D, SPRR2E, SPRR3, TGM1, TMEM79, TXNIP |
| Keratinization | 5.22 × 10−6 | SPRR1A, SPRR2A, SPRR2D, SPRR2E, SPRR3, TGM1, TMEM79 |
| Negative regulation of cell division | 2.58 × 10−5 | CDC20, FGFR3, MAD2L1, PTTG1, PTTG3P, RGCC, TXNIP, UBE2C |
| Negative regulation of mitotic nuclear division | 2.81 × 10−5 | CDC20, FGFR3, MAD2L1, PTTG1, PTTG3P, RGCC, UBE2C |
| Keratinocyte differentiation | 3.05 × 10−5 | ALOX15B, SPRR1A, SPRR2A, SPRR2D, SPRR2E, SPRR3, TGM1, TMEM79, TXNIP |
| L-serine metabolic process | 3.54 × 10−5 | CBS, PHGDH, PSAT1, SHMT2 |
| Epidermal cell differentiation | 9.21 × 10−5 | ALOX15B, RNASE1, SPRR1A, SPRR2A, SPRR2D, SPRR2E, SPRR3, TGM1, TMEM79, TXNIP |
| L-serine biosynthetic process | 9.75 × 10−5 | PHGDH, PSAT1, SHMT2 |
| Negative regulation of nuclear division | 1.10 × 10−4 | CDC20, FGFR3, MAD2L1, PTTG1, PTTG3P, RGCC, UBE2C |
| Skin development | 1.82 × 10−4 | ALOX15B, FOXQ1, FZD6, SPRR1A, SPRR2A, SPRR2D, SPRR2E, SPRR3, TGM1, TMEM79, TXNIP |
| Peptide cross-linking | 2.05 × 10−4 | SPRR1A, SPRR2A, SPRR2D, SPRR2E, SPRR3, TGM1 |
| Serine family amino acid biosynthetic process | 3.55 × 10−4 | CBS, PHGDH, PSAT1, SHMT2 |
| Regulation of collagen metabolic process | 5.84 × 10−4 | CTGF, F2R, FAP, IL6, RGCC |
| Regulation of multicellular organismal metabolic process | 6.51 × 10−4 | CTGF, F2R, FAP, IL6, RGCC |
| Steroid biosynthesis | 6.77 × 10−4 | CYP24A1, DHCR7, EBP, MSMO1 |
| Chromosome separation | 0.00192 | CDC20, MAD2L1, PTTG1, PTTG3P, TOP2A, UBE2C |
| Negative regulation of mitotic sister chromatid separation | 0.00199 | CDC20, MAD2L1, PTTG1, PTTG3P, UBE2C |
| Collagen metabolic process | 0.00200 | COL12A1, CTGF, F2R, FAP, IL6, MMP12, RGCC |
| Negative regulation of mitotic sister chromatid segregation | 0.00231 | CDC20, MAD2L1, PTTG1, PTTG3P, UBE2C |
| Multicellular organismal macromolecule metabolic process | 0.00248 | COL12A1, CTGF, F2R, FAP, IL6, MMP12, RGCC |
| Negative regulation of sister chromatid segregation | 0.00267 | CDC20, MAD2L1, PTTG1, PTTG3P, UBE2C |
| Negative regulation of chromosome segregation | 0.00267 | CDC20, MAD2L1, PTTG1, PTTG3P, UBE2C |
| Regulation of nuclear division | 0.00302 | AURKA, CDC20, FGFR3, MAD2L1, PTTG1, PTTG3P, RGCC, UBE2C |
| Multicellular organismal metabolic process | 0.00456 | COL12A1, CTGF, F2R, FAP, IL6, MMP12, RGCC |
| Regulation of collagen biosynthetic process | 0.00457 | CTGF, F2R, IL6, RGCC |
| Mitotic sister chromatid separation | 0.00664 | CDC20, MAD2L1, PTTG1, PTTG3P, UBE2C |
| Regulation of mitotic sister chromatid segregation | 0.00834 | CDC20, MAD2L1, PTTG1, PTTG3P, UBE2C |
| Sister chromatid segregation | 0.00851 | CDC20, CEP55, MAD2L1, PTTG1, PTTG3P, TOP2A, UBE2C |
| Glycine, serine and threonine metabolism | 0.00873 | CBS, PHGDH, PSAT1, SHMT2 |
| Collagen biosynthetic process | 0.00873 | CTGF, F2R, IL6, RGCC |
| Oocyte meiosis | 0.01153 | ADCY3, AURKA, CCNB2, CDC20, MAD2L1, PTTG1 |
| Regulation of sister chromatid segregation | 0.01277 | CDC20, MAD2L1, PTTG1, PTTG3P, UBE2C |
| Negative regulation of chromosome organization | 0.01396 | ARTN, CDC20, MAD2L1, PTTG1, PTTG3P, UBE2C |
| PERK-mediated unfolded protein response | 0.01404 | ASNS, ATF3, HSPA5 |
| Regulation of stress fiber assembly | 0.01630 | CTGF, RGCC, RNASE1 |
| FoxO signaling pathway | 0.01634 | CCNB2, GABARAPL1, IL6, IRS2, PCK2, SGK1 |
| Anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process | 0.01664 | AURKA, CDC20, MAD2L1, PTTG1, UBE2C |
| Alpha-amino acid biosynthetic process | 0.01664 | ASNS, CBS, PHGDH, PSAT1, SHMT2 |
| Positive regulation of collagen biosynthetic process | 0.02234 | CTGF, F2R, RGCC |
| Regulation of systemic arterial blood pressure by circulatory renin-angiotensin | 0.02412 | CPA4, F2R, MMP12 |
| Positive regulation of multicellular organismal metabolic process | 0.02412 | CTGF, F2R, RGCC |
| Secondary alcohol biosynthetic process | 0.02578 | DHCR7, EBP, HMGCS1, MSMO1 |
| Regulation of chromosome segregation | 0.02590 | CDC20, MAD2L1, PTTG1, PTTG3P, UBE2C |
| Negative regulation of proteasomal ubiquitin-dependent protein catabolic process | 0.03145 | CDC20, MAD2L1, UBE2C |
In red up-regulated and in green down-regulated genes in BE63/3 cells treated with 100 nM EVE compared to CTR.