Table 2.
Plasma l-citrulline, l-arginine, ADMA, and SDMA levels in 12-week-old male offspring exposed to high-fructose diet (HFR), high-fat (HFA) diet, and metformin (M).
| Groups | ND/ND | HFR/ND | ND/HFA | HFR/HFA | HFR/HFA+M |
|---|---|---|---|---|---|
| l-citrulline | 57.2 ± 1.1 | 51.4 ± 1 | 68.8 ± 1.5 | 56.6 ± 1.6 | 107.7 ± 7.8 a,b,c,d |
| l-arginine | 241.1 ± 4.7 | 208 ± 5.8 | 167.3 ± 8.5 a | 158.9 ± 2.1 a | 155 ± 6.6 a,b,c,d |
| ADMA | 1.01 ± 0.03 | 1.02 ± 0.04 | 0.93 ± 0.01 | 0.86 ± 0.01 | 1.8 ± 0.1 a,b,c,d |
| SDMA | 0.61 ± 0.01 | 0.58 ± 0.01 | 0.55 ± 0.01 | 0.52 ± 0.01 | 1.1 ± 0.02 a,b,c,d |
| l-arginine-to-ADMA ratio | 233 ± 1 | 202 ± 3 | 179 ± 8 a | 176 ± 3 a | 92 ± 3 a,b,c,d |
ADMA, asymmetric dimethylarginine; SDMA, symmetric dimethylarginine; a p < 0.05 vs. ND/ND; b p < 0.05 vs. HFR/ND; c p < 0.05 vs. ND/HFA; d p < 0.05 vs. HFR/HFA.