Figure 1.

The miRNAs involved in essential hypertension, their association with the RAAS, EC and VSMC and their known target genes. The big central arrows indicate a system/cell type’s influence on another and on the increase in blood pressure (BP). Small arrows in the tables indicate the upregulated (up arrow) or downregulated (down arrow) miRNA expression. Red droplets represent the biomarker potential from detectability in blood samples. EC: endothelial cells; RAAS: renin-angiotensin aldosterone system; VSMC: vascular smooth muscle cells.