Table 1.
STRING software was used to search for each BH3-only protein interactors. Only experimentally-validated interactions with a minimum score of 0.4 (medium confidence) are reported in the table. Interactors reported for HRK were identified by searching with a minimum score of 0.15 (low confidence).
| BH3-Only Proteins | p53 Transcriptional Targets | Pro-Survival Interactors | Direct Activation of BAX/BAK |
|---|---|---|---|
| BAD | No | BCL-2, BCL-XL, BFL-1, MCL-1 | - |
| BID | No | BCL-2, BCL-XL, BFL-1, MCL-1 | √ |
| BIK | No | BCL-2, BCL-XL, BCL-W | - |
| BIM | No | BCL-2, BCL-XL, BFL-1, MCL-1 | √ |
| BMF | No | BCL-2, BCL-XL, BFL-1, MCL-1 | - |
| HRK | No | BCL-2, BCL-XL, MCL-1 | - |
| NOXA | Yes | BCL-2, BCL-XL, BFL-1, MCL-1 | - |
| PUMA | Yes | BCL-2, BCL-XL, BFL-1, MCL-1 | - |