Table 1.

Cell expression, major ligands, and main functions of the αvβ3 integrin.

Cell types	Endothelial cells, smooth muscle cells, myofibroblasts, osteoclasts, monocytes, platelets, fibroblasts, tumor cells (melanoma, glioblastoma, pancreatic, prostate, ovarian, breast tumor cells), placenta
Ligands	Vitronectin, fibrinogen, von Willebrand factor, thrombospondin, prothrombin, fibronectin, fibrillins, laminin, osteopontin, bone sialoprotein
Functions	Cell adhesion, cell migration, cell survival and proliferation, growth factor deprivation-induced apoptosis rescue, anoikis rescue, angiogenesis, hemostasis, platelet aggregation, wound healing, fibrosis, inflammation, tumor cells’ invasion and metastasis, restenosis, bone resorption, activation of latent TGF-β, embryonic development