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Induction of SCCA1 and SCCA2 in inflammatory diseases. IL-17/IL-22 and IL-4/IL-13, signature cytokines of type 17 and type 2 inflammation, respectively, can induce SCCA1 and SCCA2 in keratinocytes or airway epithelial cells. IL-17/IL-22 are highly expressed in psoriasis patients, and IL-4/IL-13 are highly expressed in atopic dermatitis (AD) and asthma patients. In some AD patients, IL-17/IL-22 are also expressed.
