Table 1.
Comparison of the aa sequence of N- and C-terminal domains in beaver pep/PAG-L and various AP members.
| Protein Name a | N-Domain b | C-Domain b |
|---|---|---|
| pep/PAG-L | VLFDTGSSNLWV | GIVDTGTSLLTV |
| hPepsinogen C | ............ | A........... |
| mPepsinogen C | ............ | ..........VM |
| hPepsinogen A | .V.......... | A..........G |
| mCathepsin D | .V.......... | A.........VG |
| mNapsin A | .V.......... | A.L......I.G |
| mPepsinogen F | .VL.....V... | ..M........G |
| fPAG | .I......D... | A.I.......IG |
| TrNothepsin | .V......D... | A........IAG |
| pPAG2, 4, 6, 10 | .V......D... | A.......M.HG |
| oPAG2 | .V......D... | AL.......IHG |
| bPAG2 | .V.....A.... | ALL.....MIYG |
| mRenin | .M.....A.... | VV....S.FISA |
| mPepsinogen A | .VL.....V... | ..M........G |
| ePAG | .I.....AD... | A.........LG |
| zPAG | .I.....AD... | A.........LG |
| Pf plasmepsin I | FI.....A.... | A...S...SI.A |
| Pr plasmepsin I | FI.....A.... | VV..S...SI.A |
| pPAG1, 3, 5 | .I...A..D... | A.L.S.SAF.LG |
| Pr plasmepsin II | FIL....A.... | C...S...AI.. |
| Pf plasmepsin II | FIL....A.... | C...S...AI.. |
| Pf histo-AP | FIL....A.... | C...S...AI.. |
| Pr histo-AP | F..H.A...V.. | V.L.SA..AI.. |
a b—bovine, e—equine, f—feline, h—human, m—mouse, o—ovine, p—porcine, z—zebra, Plasmodium falciparum—Pf, Plasmodium reichenowi—Pr, Tr—Takifubu rubripes; b identical aa are dotted.