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. 2018 Apr 7;19(4):1106. doi: 10.3390/ijms19041106

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Graphs demonstrating the relative gene expression of GFAP, Gap 43, Nf-h, and Olig 2 in the spinal cord (site of the injury, cranially, and caudally) six weeks after the traumatic spinal cord injury and the ATR treatment. The lowest gene expression was observed at the lesion site. GFAP activation shows the changes in astrogliosis after the SCI and SCI + ATR (A). Markers of regenerative capacity (Gap 43, Nf-h, and Olig2) show a significant improvement in axonal outgrowing at the lesion site and in the cranial (+1) segment (B–D). The data are the mean values of five experiments ±SD. The results were statistically evaluated using a parametric T-test and one-way ANOVA; * p < 0.05; # p < 0.05; ** p < 0.01; ## p < 0.01; *** p < 0.001; **** p < 0.0001. Atorvastatin—ATR; Gap 43—outgrowing axons; GFAP—astrocytes; Nf-h—neurofilaments (heavy); Olig2—oligodendrocytes; SCI—spinal cord injury.