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. 2018 Mar 27;19(4):1006. doi: 10.3390/ijms19041006

Figure 3.

Figure 3

CRRL269 possesses enhanced pGC-A activator in vitro in human renal cells. CRRL269 generated significantly higher cGMP in HEK293 cells overexpressing pGC-A receptors (HEK pGC-A) and human renal proximal tubular cells (RPTC) compared to BNP or URO. Cells were treated with Hank’s balanced salt solution (HBSS, as negative control, neg ctrl), BNP, URO or CRRL269 for 10 min and cell lysates were collected for cGMP radioimmunoassay. * p < 0.05, versus neg ctrl, † p < 0.05, versus BNP, # p < 0.05, versus URO. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology [27].