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. 2018 Mar 27;19(4):1006. doi: 10.3390/ijms19041006

Figure 4.

Figure 4

CRRL269 as an enhanced pGC-A activator in vivo in normal canines (n = 5). CRRL269 induced significantly higher and sustained diuresis (urine output, UV), natriuresis (urinary sodium excretion, UNaV), GFR, and lower blood pressure (mean arterial pressure, MAP) compared to BNP or URO. Acute studies were performed with intravenous infusion of low dose 2 pmol/kg/min and high dose 33 pmol/kg/min BNP, URO or CRRL269 in normal canines. Data are calculated from the difference from baseline. BL = baseline; Low = infusion of low dose 2 pmoL/kg/min BNP, URO or CRRL269; High = infusion of high dose 33 pmoL/kg/min; Wo = washout (0–30 min post-infusion); Rec1 = recovery 1, 30–60 min post-infusion; Rec2 = recovery 2, 60–90 min post-infusion. * p < 0.05, versus baseline (1-way ANOVA and Dunnett post-tests), † p < 0.05, versus BNP, # p < 0.05, versus URO (2-way ANOVA and Bonferroni post-hoc tests). American Journal of Physiology-Regulatory, Integrative and Comparative Physiology [27].