Figure 5.

A comparative study of the arsenic uptake and toxic response of different drug formulations on HeLa and HT-3 cells. (a) Comparison of the arsenic uptake by HeLa and HT-3 after 6, 24, and 48 h of treatment—as determined by inductively coupled plasma mass spectrometry (ICP-MS). Free ATO was taken up more than ATO lipo in both cell lines. However, the uptake was higher in HT-3 for all treatments, except for the free ATO uptake after 48 h. (b) Ratios of toxicity vs. uptake of liposomal and free ATO for the two cervical cancer cell lines after 24 h treatment. Data are displayed as mean ± SD from at least three independent experiments; * p < 0.05, ** p < 0.01, and *** p < 0.001.