Figure 6.

Arsenic uptake and toxic response in the control cells and HeLa cells. (a) A comparative study of arsenic concentration per cell in CRL-1790, human epidermal keratinocyte (HK), and HeLa—as determined via ICP-MS after 24 h of treatment with media, control liposomes, ATO lipo, and free ATO; (b) Cell survival following the exposure of cervical cancer and control cell lines to ATO lipo for 24 h—assessed using the MTT assay; (c) Toxicity–uptake ratio of ATO lipo and free ATO in HeLa cells compared to control cell lines, after treatment for 24 h. ATO lipo is effective in generating toxicity in HeLa cells, while having a non-toxic effect on the normal cells; (d) The IC₅₀ values for three cell lines following 24 h of ATO liposomal treatment. Data are displayed as mean ± SD from three replicates; * p < 0.05, ** p < 0.01.