Table 2.

Correlations of serum SL’s of patients post-OLT with age of patients and grafts, biochemical parameters and time between OLT and inclusion.

SL	Patients’ Age at BW	AST	ALT	GGT	Chol	TG	Tacrolimus Though Level	Grafts’ Age at BW	Time Between OLT and BW
Sphingosine	0.149	0.030	0.147	0.062	0.120	0.095	−0.0001	0.104	−00.031
Sphinganine	0.047	0.036	0.194 *	0.049	0.082	0.065	−0.039	0.114	−0.031
S1P	−0.014	0.069	0.171 *	0.059	0.225 **	0.114	0.027	−0.111	−0.014
dhS1P	−0.046	0.104	0.211 **	0.049	0.211 **	0.165 *	0.037	−0.040	0.030
C24Cer	0.214 **	−0.296 ***	−0.050	−0.145	0.606 ***	0.429 ***	0.159	−0.110	−0.186 *
C16Cer	0.059	0.065	0.016	0.164 *	0.205 **	0.124	−0.079	0.081	−0.199 *
C14Cer	0.069	0.037	0.125	0.101	0.284 ***	0.129	−0.014	−0.018	−0.096
C18Cer	0.308 ***	−0.029	0.115	0.203 *	0.427 ***	0.455 ***	−0.051	−0.086	−0.142
C20Cer	0.306 ***	−0.215 **	−0.071	0.060	0.396 ***	0.418 ***	0.007	−0.154	−0.167 *
C18:1Cer	0.031	−0.041	−0.0003	0.022	0.217 **	0.136	0.008	0.075	−0.094
C24:1Cer	0.291 ***	−0.153	−0.004	0.082	0.401 ***	0.444 ***	0.108	−0.197 *	−0.208 *
C16DHC	−0.010	0.142	0.076	0.137	0.039	0.040	−0.082	0.106	−0.072
C18DHC	0.273 ***	−0.034	0.078	0.142	0.284 ***	0.377 ***	−0.071	0.030	−0.093
C24DHC	0.161	−0.104	0.101	−0.055	0.529 ***	0.313 ***	0.062	0.001	−0.130
C24:1DHC	0.199 *	0.109	0.213 **	0.186 *	0.317 ***	0.272 ***	−0.063	0.033	−0.040

Correlations are evaluated by Spearman’s rank correlation coefficient rho (r). Significant correlations are indicated in the corresponding figures: * p < 0.05; ** p < 0.01; *** p < 0.001. Abbreviations: SL, sphingolipid; OLT, orthopic liver transplantation; AST, aspartate transferase; ALT, alanine transferase; GGT, gamma glutamyl transferase; Chol, cholesterol; TG, triglyceride; BW, blood withdrawal; S1P, sphingosine-1-phosphate; dhS1P, sphinganine-1-phosphate; Cer, ceramide; DHC, dihydroceramide. Missing data: GGT was missing for 1 patient, tacrolimus through levels were missing for 2 patients with current tacrolimus intake, missing age of graft in 37 cases.