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. 2018 Mar 23;19(4):953. doi: 10.3390/ijms19040953

Figure 5.

Figure 5

Quetiapine regulates antioxidant stress by the p38 MAPK pathway to resist UV damage. Changes in p-p38 following irradiation in different groups are shown in Figure 5. (A) Representative images of p-p38 in the skin of the different groups at the 24 h time point after irradiation, the result of western blot analysis is indicated by the grey level; (B) The statistical analysis of the grey level. (* represents the comparison between UVB group and control group, ※ represents the comparison between UVB group and quetiapine group, * p < 0.05, ※ p < 0.05); (C) Representative images of p-p38 in HaCaT cells of the different groups at the 24 h time point after irradiation; (D) The statistical analysis of the grey level. (* represents the comparison between UVB group and control group, ※ represents the comparison between UVB group and quetiapine group, * p < 0.05, ※ p < 0.05); (E) SOD activity with the activity of p38 inhibited at 24 h after UVB irradiation; (F) GSH-Px with the activity of p38 inhibited at 24 h after UVB irradiation; (G) MDA levels with the activity of p38 inhibited at 24 h after UVB irradiation; Data are expresses as mean ± S.D., n = 5. * p < 0.05. (* Represents the comparison between quetiapine group and UVB group).