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Regulation of telomerase by different miRNAs (A). miR-615-3p (B) is transcribed from HOXC5 (C). Both HOXC5 and miR-615-3p negatively regulated TERT. HOXC5 promoted loading of PBX4 and MEIS3 to repress TERT. HOXC5, one of several homeobox HOXC genes located in a cluster on chromosome 12; PBX4, pre-B-cell leukemia transcription factor 4; MEIS3, Meis homeobox-3.
