Skip to main content
. 2018 Apr 5;19(4):1087. doi: 10.3390/ijms19041087

Table 2.

The in vivo effects of acid exposure on the regulation of major epithelial ion transporters in zebrafish ionocytes and mammalian renal cells.

Ion Transporters Expression Levels/Activity
Zebrafish * Mammals
H+-ATPase Chronic:
↑ H+-ATPase mRNA expression
↑ H+-ATPase activity
↑ HRCs density [12,38,39]		 Acute:
↑ H+-ATPase mRNA (rabbit) [40]
Chronic:
↑ H+-ATPase protein abundance (rabbit) [41]
NHE3 Chronic:
↑ nhe3b mRNA expression [38]
↑ NHE3b activity [42]		 Chronic:
↑ NHE3 protein abundance (rat) [43,44]
↑ NHE activity (rat) [45]
AE1 Chronic:
↑ ae1b mRNA expression [38]		 Chronic
↑ AE1-expressing cells
↑ AE1 protein abundance (rabbit) [46]
NCC Acute:
↔ ncc mRNA expression
↔ NCCCs density
↑ NCC activity [26]		 Acute:
↔ NCC protein abundance (rat) [47]
Chronic:
↑ ncc mRNA expression
↑ NCCCs density [48]		 Chronic:
↑ NCC protein abundance (rat) [47]
ECaC Chronic:
↑ ecac-expressing cells
↑ ECaC activity [49]		 Chronic:
↓ ecac (TRPV5) mRNA expression
↓ ECaC protein abundance (mice) [50]

↑ Increase, ↓ decrease, ↔ no change. * Regulation of ion transporters at larval stages (0 to 4 days post-fertilization). Acute: ≤24 h of exposure, chronic: >1 day of exposure.