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. 2018 Apr 13;19(4):1196. doi: 10.3390/ijms19041196

Figure 3.

Figure 3

Calsenilin regulates RhoA inactivation and the RhoA-ROCK-LIMK-cofilin pathway in the mouse brain:(A) detection of RhoA-GTP levels in the brain of wild-type (WT) and calsenilin knockout (KO) mice; (B) phosphorylation levels of RhoA, LIMK, and cofilin in the whole brain lysates of WT and calsenilin-KO mice; and (C) co-immunoprecipitation of RhoA with calsenilin (anti-4E4) [19] and p190RhoGAP in the whole brain lysates of WT and calsenilin-KO mice. The intensities of the bands in each panel were measured and quantified for each group, and the values are expressed as the mean SEM of three independent experiments (n = 3, * p < 0.05; *** p < 0.001).