UDCA |
ursodeoxycholate |
GUDCA |
glycine ursodeoxycholate |
TUDCA |
taurousodeoxycholate |
EE |
17α-ethinylestradiol |
Mrp2/MRP2 |
multidrug resistance-associated protein 2 |
MTX |
methotrexate |
GSH |
reduced gluthathione |
Nrf2 |
nuclear factor-E2-released factor 2 |
Ntcp |
Na+-taurocholate co-transporting polypeptide |
Oat |
organic anion transporter |
Oatp |
organic anion transporting polypeptide |
Bsep |
bile salt export pump |
ALT |
alanine aminotransferase |
AST |
aspartate aminotransferase |
PG |
propylene glycol |
CMC |
carboxymethyl cellulose |
BUN |
blood urea nitrogen |
PBS |
phosphate buffered saline |
LC-MS/MS |
liquid chromatography tandem-mass spectrometry |
RT-PCR |
real-time reverse-transcription polymerase chain reaction |
Hprt |
hypoxanthine phosphoribosyltransferase |
IS |
internal standard |
SDS-PAGE |
sodium dodecyl sulfate-polyacrylamide gel electrophoresis |
β-NAD |
β-nicotinamide adenine dinucleotide |
3α-HSD |
3α-hydroxysteroid dehydrogenase |
EDTA |
ethylenediaminetetraacetic acid |
AUC |
area under the plasma concentration–time curve |
CLtotal
|
total clearance |
CLurine
|
urinary clearance |
CLbile
|
biliary clearance |
GFR |
glomerular filtration rate |
CLcr
|
creatinine clearance |
CLGF
|
glomerular filtration clearance |
CLup,liver
|
liver uptake clearance |
CLup,kidney
|
kidney uptake clearance |
CLexc,bile
|
biliary excretion clearance |
CLexc,urine
|
urinary excretion clearance |