Table 3.
Pharmacokinetic parameters of MTX following intravenous injection of MTX at a dose of 3 mg/kg.
| Parameters/Groups | Control (n = 3) | EE (n = 4) | UDCA + EE/UDCA (n = 4) | |
|---|---|---|---|---|
| C0 | μg/mL | 21.7 ± 5.0 | 36.9 ± 4.6 * | 29.3 ± 2.1 *,# |
| AUC6h | μg·min/mL | 320.5 ± 68.4 | 1167.8 ± 235.6 * | 441.7 ± 104.8 # |
| AUC∞ | μg·min/mL | 325.1 ± 71.9 | 1275.4 ± 341.9 * | 445.9 ± 106.6 # |
| t1/2 | min | 59.1 ± 14.9 | 105.1 ± 37.0 | 61.9 ± 8.6 |
| CLtotal | mL/min/kg | 9.56 ± 2.2 | 2.47 ± 0.6 * | 7.02 ± 1.6 # |
| CLbile | mL/min/kg | 6.71 ± 2.0 | 1.54 ± 0.6 * | 5.55 ± 1.3 # |
| CLurine | mL/min/kg | 3.69 ± 1.1 | 1.00 ± 0.2 * | 2.02 ± 0.5 *,# |
Data were expressed as mean ± SD from three or four different rats per group. * p < 0.05, significant compared with control group by student’s t-test. # p < 0.05, significant compared with EE group by student’s t-test. C0: initial plasma concentration. AUC6h or AUC∞: Area under plasma concentration-time curve from zero to 6 h or infinity. t1/2: elimination half-life. CLtotal: total CL (Dose/plasma AUC). CLbile: biliary CL (Excreted amount in bile/plasma AUC). CLurine: urinary CL (Excreted amount in urine/plasma AUC).