Table 5.
Hepatobiliary and renal excretion of MTX following intravenous injection of 1 mg/kg and infusion of 0.6 mg/kg/h for 6 h of MTX.
| Parameters/Groups | Control (n = 3) | EE (n = 4) | UDCA + EE/UDCA (n = 4) |
|---|---|---|---|
| CLexc,bile (mL/min/kg) | 5.63 ± 0.3 | 0.34 ± 0.2 * | 4.09 ± 0.9 # |
| CLGF (mL/min/kg) | 1.09 ± 0.02 | 0.81 ± 0.01 | 0.83 ± 0.01 |
| CLexc,urine (mL/min/kg) | 2.60 ± 1.1 | 0.06 ± 0.2 * | 1.20 ± 0.5 *,# |
Data were expressed as mean ± SD from three or four different rats per group. * p < 0.05, significant compared with control group by student’s t-test. # p < 0.05, significant compared with EE group by student’s t-test. CLexc,bile: biliary excretion CL (MTX excretion rate into bile/MTX concentration in the liver at steady state. CLGF: glomerular filtration CL (creatinine CL (GFR) × unbound fraction of MTX). CLexc,urine urinary excretion CL (CLurine − CLGF).