Table 2.
The detected significant Gene Ontology terms based on miRNAs differentially expressed between pigs differing in terms of muscle mass.
| GO | Detected miRNA | N | Most Interesting Genes Related with GO Term | p-Value |
|---|---|---|---|---|
| Cell cycle (hsa04110) | 1.026 × 10−9 | |||
| hsa-let-7i-5p | 32 | CDK4; CDK2; CDK6; TP53; RBL2; ESPL1; ORC2 | ||
| hsa-let-7g-5p | 33 | CDK4; CDK2; CDK6; TP53; RBL2; ESPL1; ORC2 | ||
| hsa-miR-30a-5p | 24 | PCNA; SMAD2; TP53; MYC; YWHAE | ||
| hsa-let-7f-5p | 35 | ESPL1; CCNB2; RBL2; SMC1A; CDK4; TP53; ATR | ||
| hsa-miR-499a-5p | 7 | YWHAG; E2F5; SKP2; MYC; CDC27; PRKDC; MDM2 | ||
| hsa-miR-146a-5p | 12 | GSK3B; CCNB1; CCNA2; SMAD4; RBL1; CDC23; PRKDC; MDM2; ABL1 | ||
| hsa-miR-378a-3p | 20 | CCNB1; YWHAG; CCND2; MCM4; CDK1; BUB3; MDM2 | ||
| hsa-miR-10b-5p | 13 | YWHALE; CDK2; CCND2; CUL1; TP53; CDC27 | ||
| hsa-miR-7-5p | 20 | YWHAH; YWHAE; CCNB1; E2F2; CDK2; ATM; | ||
| hsa-miR-26a-5p | 32 | CDC6; CCNB1; YWHAE; YWHAG; YWHAZ; SMAD4; WEE1; EP300 | ||
| hsa-miR-185-5p | 16 | CDK4; YWHAE; YWHAG; YWHAB; YWHAQ; ORC4; | ||
| hsa-miR-126-3p | 4 | E2F1; E2F3; CCNE2; CCNE1 | ||
| hsa-miR-125b-5p | 19 | CDC6; E2F2; E2F3; ATR; TP53; CUL1; ORC5 | ||
| hsa-miR-206 | 9 | CDK4; CCND2; CDC7; WEE1; MCM7; CDC25C | ||
| Fatty acid biosynthesis (hsa00061) | ||||
| hsa-miR-30a-5p | 4 | FASN; ACSL1; ACSL3; ACSL4 | 6.038 × 10−9 | |
| hsa-miR-26a-5p | 4 | FASN; ACSL1; ACSL3; ACSL4 | ||
| hsa-miR-378a-3p | 2 | ACSL4; ACACA | ||
| hsa-miR-7-5p | 4 | FASN; OXSM; ACACA; ACSL4 | ||
| hsa-let-7i-5p | 1 | MCAT | ||
| hsa-let-7g-5p | 1 | MCAT | ||
| hsa-let-7f-5p | 1 | MCAT | ||
| hsa-miR-125b-5p | 1 | FASN | ||
| Regulation of actin cytoskeleto n (hsa04810) | 0.0218 | |||
| hsa-let-7i-5p | 31 | PPP1CA; PFN1; BRAF; ACTB; SSH2; CRK; GNA13; FN1; RAC1; VAV3; MAPK1; FGFR1 | ||
| hsa-let-7g-5p | 31 | PPP1CA; PFN1; BRAF; ACTB; SSH2; CRK; GNA13; FN1; RAC1; VAV3; MAPK1; FGFR1 | ||
| hsa-miR-125b-5p | 27 | SSH2; EZR; NRAS; CRKL; CRK; PAK2; PXN; MYL9; FGFR2; FGFR1; MYH9 | ||
| hsa-let-7f-5p | 32 | PPP1CA; PFN1; BRAF; ACTB; SSH2; CRK; GNA13; FN1; RAC1; VAV3; MAPK1; FGFR1 | ||
| hsa-miR-378a-3p | 17 | ACTB; SSH2; ITGA9; CRKL; GNA13; PFN2; PAK4; MAPK1; MYLK | ||
| hsa-miR-146a-5p | 9 | BRK1; ROCK1; WASL; EDFR; ACTN1; ITGB2; WASF2 | ||
| hsa-miR-7-5p | 35 | ACTB; ACTN2; NRAS; APC; RRAS2; FN1; FGF1; ACTN4; MAPK1; PIK3CB; EGFR | ||
| hsa-miR-185-5p | 14 | PIP5K1C; FN1; MYLK; ENAH; CDC42; ITGB5; RHOA; EGFR; PPP1CC | ||
| hsa-miR-378b | 4 | SSH2; ITGB1; ROCK2; MSN | ||
| hsa-miR-26a-5p | 32 | SSH2; EZR; NRAS; CRK; ITGA8; PAK1; ITGB3; ITGA6 | ||
| hsa-miR-30a-5p | 29 | ARPC5; WASL; NRAS; SSH1; GNA13; EGFR; FN1; RAC1; PIK3CA; PPP1CB | ||
| hsa-miR-10b-5p | 6 | CRK; ARPC5; ACTG1; TIAMI; PIK3CD; DIAPH2 | ||
| hsa-miR-126-3p | 8 | PIK3CA; PIK3CD; ITGA6; MAPK1; KRAS; CRK; PIK3R2 | ||
| hsa-miR-451a | 3 | BRAF; WASL; PIK3CA | ||
| hsa-miR-206 | 2 | EGFR; FN1 | ||
| hsa-miR-499a-5p | 2 | CFL2; FGF2 | ||
| Lysine degradation (hsa00310) | ||||
| hsa-let-7i-5p | 12 | WHC1L1; SETD1B; PLOD2; ASHIL; SETD1A; KMT2B | 7.854 × 10−7 | |
| hsa-let-7g-5p | 11 | PLOD2; SETD1B; ASH1L; DOT1L; KMT2D; KMT2E | ||
| hsa-miR-125b-5p | 7 | KMT2D; WHSC1; KMT2C; KMT2B; SUV39H1; SUV420H2 | ||
| hsa-let-7f-5p | 12 | ALDH7A1; SETD1B; KMT2D; DOT1L; SETD1A; KMT2B; KMT2E | ||
| hsa-miR-7-5p | 15 | ALDH3A2; SETD1B; PLOD2; PLOD1; SETD2; NSD1; OGDH; | ||
| hsa-miR-378a-3p | 4 | SETD7; ASH1L; KMT2D; SUV420H1 | ||
| hsa-miR-30a-5p | 12 | SETD7; PLOD2; OGDH; NSD1; SETD2; ALDH2 | ||
| hsa-miR-185-5p | 3 | ASHIL; KMT2D; WHSC1 | ||
| hsa-miR-10b-5p | 4 | SETD7; SUV420H1; WHSC1L1; ALDH3A2 | ||
| hsa-miR-26a-5p | 9 | SETD2; NSD1; ACAT2; SETD8; SETDB1; KMT2D; KMT2C; KMT2A; ALDH9A1 | ||
| hsa-miR-146a-5p | 2 | NSD1; KMT2C | ||
| Ubiquitin mediated proteolysis (hsa04120) | ||||
| hsa-let-7i-5p | 29 | BCBL; MAP3KI; UBE3B; BTRC; HUWEI; SKP2; NEDD4L; MID1U; BOX5 | 9.766 × 10−5 | |
| hsa-let-7g-5p | 30 | UBE3B; CBL; CUL2; NEDD4L; MAP3K1; MID1; BIRC3; UBOX5; SKP2 | ||
| hsa-miR-30a-5p | 42 | UBE3B; CUL2; NEDD4L; MAP3K1; MID1; BIRC3; UBOX5; SKP2; UBA6; SEA1 | ||
| hsa-let-7f-5p | 29 | UBE2Z; CBL; UBE2R2; UBR5; STUB1; XIAP; FBXW7; BIRC6 | ||
| hsa-miR-7-5p | 23 | UBE2Z; CBL; UBE2R2; UBR5; STUB1; XIAP; FBXW7; BIRC6 | ||
| hsa-miR-26a-5p | 23 | WWP2; SMURF2; HUWE1; SKP1; BRCA1; CDC23; MDM2; | ||
| hsa-miR-378a-3p | 9 | UBE2Z; CBL; BTRC; FBXW7; HUWE1; PML; RBX1; MDM2 | ||
| hsa-miR-206 | 1 | BRCA1 | ||
| hsa-miR-146a-5p | 6 | ITCH; MID1; BRCA1; TRAF6; CDC23; MDM2 | ||
| hsa-miR-10b-5p | 11 | UBE2Z; UBE3B; CUL1; BRCA1; NEDD4; CDC27; MDM2 | ||
| hsa-miR-185-5p | 12 | UBE2Z; UBR5; HUWE1; BIRC6; MDM2; TRIP12; UBE4A | ||
| hsa-miR-125b-5p | 10 | HUWE1; CUL1; UBA6; BIRC6; SAE1; CDC27; XIAP | ||
| hsa-miR-499a-5p | 4 | SKP2; CDC27; MDM2; KLHL9 | ||
| hsa-miR-126-3p | 2 | UBE2K; FBXW11 | ||
| hsa-miR-378b | 1 | RBX1 | ||