Table 3.
The pathways and genes regulated by identified miRNAs (N-number of genes regulated in each pathway).
| Pathway | miRNA Involved in Pathway Regulation | n | Target Genes | p-Value |
|---|---|---|---|---|
| Hippo signaling pathway (hsa04390) | hsa-miR-499a-5p; hsa-miR-30a-5p, hsa-miR-7-5p; hsa-let-7i-5p; hsa-let-7g-5p; hsa-miR-125b-5p; hsa-let-7f-5p; hsa-miR-26a-5p; hsa-miR-185-5p; hsa-miR-146a-5p;hsa-miR-10b-5p; hsa-miR-378a-3p; hsa-miR-451a; hsa-miR-126-3p; hsa-miR-206; hsa-miR-378b | 87 | PPP1CA; ACTB; TGFBR1; BMP5; BMPR1B; WNT5A; YWHAE; WNT10B; WNT3A; WNT8B; BMP2; YWHAB; YWHAQ; MOB1B; SMAD4; BMP4; SOX2; BMPR2 | 6.038 × 10−9 |
| FoxO signaling pathway (hsa04068) | hsa-let-7i-5p; hsa-let-7g-5p; hsa-let-7f-5p; hsa-miR-206; hsa-miR-378a-3p; hsa-miR-30a-5p; hsa-miR-7-5p; hsa-miR-185-5p; hsa-miR-26a-5p; hsa-miR-126-3p; hsa-miR-499a-5p; hsa-miR-146a-5p; hsa-miR-451a; hsa-miR-125b-5p; hsa-miR-10b-5p | 88 | BRAF; NRAS; KRAS; TGFBR1; TGFBR2; PIK3R2; FBX032; IGFR; SIRT1; IRS2; FOXO6; FOXO3; USP7 | 2.159 × 10−8 |
| TGF-β signaling pathway (hsa04350) | hsa-miR-10b-5p; hsa-let-7i-5p; hsa-let-7g-5p; hsa-miR-30a-5p; hsa-let-7f-5p; hsa-miR-26a-5p;hsa-miR-378a-3p; hsa-miR-499a-5p; hsa-miR-451a; hsa-miR-7-5p; hsa-miR-126-3p, hsa-miR-146a-5p; hsa-miR-125b-5p; hsa-miR-185-5p; hsa-miR-378b; hsa-miR-206 | 50 | FST; TGFBR1; ID2; ID4; ROCK1; SMAD2; SMAD3; SMAD4; SMAD7; SP1; BMP4; BMP2; BMP5; BMPR1B; BMPR2; MAPK1 | 1.357 × 10−6 |
| PI3K-Akt signaling pathway (hsa04151) | hsa-miR-30a-5p; hsa-miR-7-5p; hsa-let-7i-5p; hsa-miR-10b-5p; hsa-let-7g-5p; hsa-let-7f-5p; hsa-miR-125b-5p;hsa-miR-185-5p; hsa-miR-206; hsa-miR-378a-3p; hsa-miR-26a-5p; hsa-miR-499a-5p; hsa-miR-146a-5p; hsa-miR-126-3p;hsa-miR-451a;hsa-miR-378b | 167 | TLR2; PRLR; MET; ITGB1; ATF2; CDK2; GNG5; GNG11; GNG12; CDK2; STK11; CK6; IGF1R; EGFR; TP53; PIK3CD; PIK3R3; FGF9; ITGA5; FGF1 | 0.016 |
| Signaling pathways regulating pluripotency of stem cells (hsa04550) | hsa-miR-125b-5p; hsa-miR-30a-5p; hsa-miR-378a-3p; hsa-miR-10b-5p; hsa-let-7i-5p; hsa-let-7g-5p; hsa-let-7f-5p; hsa-miR-7-5p; hsa-miR-26a-5p; hsa-miR-146a-5p; hsa-miR-185-5p; hsa-miR-126-3p; hsa-miR-499a-5p; hsa-miR-451a | 86 | SOX2; KLF4; PAX6; PIK3R2; FZD3; MAPK13; KRAS; SMAD6; NRAS; IGF1R; TBX3; LIF; MYC; BPO2; FGF2; LIFR; CTNNB1; PIK3CA; SMP4; BMPR2; JAKI | 1.27 × 10−6 |