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. 2018 Apr 7;19(4):1108. doi: 10.3390/ijms19041108

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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(A) Effect of sesamol and H-89 (PKA/MSK inhibitor) on melanin content (%) in α-MSH-treated B16F10 cells after 48 h. Each value is presented as the mean ± SD. ^### p < 0.001 (Significant difference versus control); *** p < 0.001 (Significant difference versus α-MSH treated group). (B) Effects of sesamol and H-89 (PKA/MSK inhibitor) on protein expression of tyrosinase in α-MSH-treated B16F10 cells after 48 h. Each value is presented as the mean ± SD. ^### p < 0.001 (Significant difference versus control); *** p < 0.001 (Significant difference versus α-MSH treated group). (C) Effects of sesamol and LY 294002 (PI3K inhibitor) on melanin content (%) in α-MSH-treated B16F10 cells after 48 h. Each value is presented as the mean ± SD. ^### p < 0.001 (Significant difference versus control); *** p < 0.001 (Significant difference versus α-MSH treated group). (D) Effects of sesamol and LY 294002 (PI3K inhibitor) on protein expression of tyrosinase in α-MSH-treated B16F10 cells after 48 h. Each value is presented as the mean ± SD. ** p < 0.01, *** p < 0.001 (Significant difference versus α-MSH treated group).